BDBM163619 UF010::US10807944, Compound UF010
SMILES: CCCCNNC(=O)c1ccc(Br)cc1
InChI Key: InChIKey=BVQCFCYPFJOOAV-UHFFFAOYSA-N
Data: 21 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | 8.0 | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cereblon/Histone deacetylase 6 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 9.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida Research Foundation, Inc.; The Scripps Research Institute US Patent | Assay Description These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic... | US Patent US10807944 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 3 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | 8.0 | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | 8.0 | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cereblon/Histone deacetylase 6 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.10E+3 | n/a | n/a | n/a | n/a | 8.0 | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 10 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.53E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 11 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.45E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 4 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 5 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 7 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 9 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HDAC1/NCOR2 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HDAC2/NCOR2 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HDAC3/NCOR2 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cereblon/Histone deacetylase 6 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cereblon/Histone deacetylase 1 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida Research Foundation, Inc.; The Scripps Research Institute US Patent | Assay Description These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic... | US Patent US10807944 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cereblon/Histone deacetylase 2 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida Research Foundation, Inc.; The Scripps Research Institute US Patent | Assay Description These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic... | US Patent US10807944 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 3 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida Research Foundation, Inc.; The Scripps Research Institute US Patent | Assay Description These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic... | US Patent US10807944 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida Research Foundation, Inc.; The Scripps Research Institute US Patent | Assay Description These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic... | US Patent US10807944 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 2 (Homo sapiens (Human)) | BDBM163619 (UF010 | US10807944, Compound UF010) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | 8.0 | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair |