BDBM163719 3-Cyclohexyl-5-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-4,5-dihydro-1,2,4-triazin-6(1H)-one (18)
SMILES: COc1ccccc1N1CCN(CCCCC2NC(=NNC2=O)C2CCCCC2)CC1
InChI Key: InChIKey=ZLZUHWMDENIQAS-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM163719 (3-Cyclohexyl-5-{4-[4-(2-methoxyphenyl)piperazin-1-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 5 | -11.3 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Jagiellonian University Medical College | Assay Description All assays were incubated in a total volume of 200 mL in 96-well microtiter plates for 1 h at 37 °C, except for 5-HT1ARs which were incubated at room... | Chem Biol Drug Des 86: 697-703 (2015) Article DOI: 10.1111/cbdd.12539 BindingDB Entry DOI: 10.7270/Q2DR2T86 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 7 (Homo sapiens (Human)) | BDBM163719 (3-Cyclohexyl-5-{4-[4-(2-methoxyphenyl)piperazin-1-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 20 | -10.5 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Jagiellonian University Medical College | Assay Description All assays were incubated in a total volume of 200 mL in 96-well microtiter plates for 1 h at 37 °C, except for 5-HT1ARs which were incubated at room... | Chem Biol Drug Des 86: 697-703 (2015) Article DOI: 10.1111/cbdd.12539 BindingDB Entry DOI: 10.7270/Q2DR2T86 | |||||||||||
More data for this Ligand-Target Pair |