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BDBM163764 US9062070, 19

SMILES: Fc1ccc([C@H]2CN3CCN(C[C@H]3CO2)C(=O)C2CCc3nc(ccc23)-n2cnnn2)c(F)c1[N+]#[C-]

InChI Key: InChIKey=KYXVVLWRZVDBNP-RSZFBLLVNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 163764   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Renal Outer Medullary Potassium (ROMK)


(Rattus norvegicus (Rat))
BDBM163764
PNG
(US9062070, 19)
Show SMILES Fc1ccc([C@H]2CN3CCN(C[C@H]3CO2)C(=O)C2CCc3nc(ccc23)-n2cnnn2)c(F)c1[N+]#[C-] |r|
Show InChI InChI=1/C24H22F2N8O2/c1-27-23-18(25)5-2-17(22(23)26)20-11-32-8-9-33(10-14(32)12-36-20)24(35)16-3-6-19-15(16)4-7-21(29-19)34-13-28-30-31-34/h2,4-5,7,13-14,16,20H,3,6,8-12H2/t14-,16?,20+/s2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 420n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


US Patent US9062070 (2015)


BindingDB Entry DOI: 10.7270/Q2WQ02JX
More data for this
Ligand-Target Pair
Renal Outer Medullary Potassium (ROMK)


(Rattus norvegicus (Rat))
BDBM163764
PNG
(US9062070, 19)
Show SMILES Fc1ccc([C@H]2CN3CCN(C[C@H]3CO2)C(=O)C2CCc3nc(ccc23)-n2cnnn2)c(F)c1[N+]#[C-] |r|
Show InChI InChI=1/C24H22F2N8O2/c1-27-23-18(25)5-2-17(22(23)26)20-11-32-8-9-33(10-14(32)12-36-20)24(35)16-3-6-19-15(16)4-7-21(29-19)34-13-28-30-31-34/h2,4-5,7,13-14,16,20H,3,6,8-12H2/t14-,16?,20+/s2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9062070 (2015)


BindingDB Entry DOI: 10.7270/Q2WQ02JX
More data for this
Ligand-Target Pair