BDBM163825 US9062070, 80

SMILES: Fc1ccc(cc1[N+]#[C-])[C@@H]1CN2CCN(C[C@@H]2CO1)C(=O)C1CCc2nc(ncc12)-n1cnnn1

InChI Key: InChIKey=UYACTOHYTKXHNZ-RWPZGMTISA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 163825   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Renal Outer Medullary Potassium (ROMK) (Rattus norvegicus (Rat))	BDBM163825 (US9062070, 80) Show SMILES Fc1ccc(cc1[N+]#[C-])[C@@H]1CN2CCN(C[C@@H]2CO1)C(=O)C1CCc2nc(ncc12)-n1cnnn1 |r| Show InChI InChI=1S/C23H22FN9O2/c1-25-20-8-14(2-4-18(20)24)21-11-31-6-7-32(10-15(31)12-35-21)22(34)16-3-5-19-17(16)9-26-23(28-19)33-13-27-29-30-33/h2,4,8-9,13,15-16,21H,3,5-7,10-12H2/t15-,16?,21+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...				US Patent US9062070 (2015) BindingDB Entry DOI: 10.7270/Q2WQ02JX
					More data for this Ligand-Target Pair
Renal Outer Medullary Potassium (ROMK) (Rattus norvegicus (Rat))	BDBM163825 (US9062070, 80) Show SMILES Fc1ccc(cc1[N+]#[C-])[C@@H]1CN2CCN(C[C@@H]2CO1)C(=O)C1CCc2nc(ncc12)-n1cnnn1 |r| Show InChI InChI=1S/C23H22FN9O2/c1-25-20-8-14(2-4-18(20)24)21-11-31-6-7-32(10-15(31)12-35-21)22(34)16-3-5-19-17(16)9-26-23(28-19)33-13-27-29-30-33/h2,4,8-9,13,15-16,21H,3,5-7,10-12H2/t15-,16?,21+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...				US Patent US9062070 (2015) BindingDB Entry DOI: 10.7270/Q2WQ02JX
					More data for this Ligand-Target Pair