BDBM163847 US9062070, 102

SMILES: Cc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CN1)C(=O)C1CCc2nc(ncc12)-n1cnnn1

InChI Key: InChIKey=BNDARHVEYNVOHK-IKZMBGHXSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 163847   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Renal Outer Medullary Potassium (ROMK) (Rattus norvegicus (Rat))	BDBM163847 (US9062070, 102) Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CN1)C(=O)C1CCc2nc(ncc12)-n1cnnn1 |r| Show InChI InChI=1S/C24H25FN10O/c1-14-16(3-5-19(25)22(14)26-2)21-12-33-7-8-34(11-15(33)9-27-21)23(36)17-4-6-20-18(17)10-28-24(30-20)35-13-29-31-32-35/h3,5,10,13,15,17,21,27H,4,6-9,11-12H2,1H3/t15-,17?,21-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...				US Patent US9062070 (2015) BindingDB Entry DOI: 10.7270/Q2WQ02JX
					More data for this Ligand-Target Pair
Renal Outer Medullary Potassium (ROMK) (Rattus norvegicus (Rat))	BDBM163847 (US9062070, 102) Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CN1)C(=O)C1CCc2nc(ncc12)-n1cnnn1 |r| Show InChI InChI=1S/C24H25FN10O/c1-14-16(3-5-19(25)22(14)26-2)21-12-33-7-8-34(11-15(33)9-27-21)23(36)17-4-6-20-18(17)10-28-24(30-20)35-13-29-31-32-35/h3,5,10,13,15,17,21,27H,4,6-9,11-12H2,1H3/t15-,17?,21-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...				US Patent US9062070 (2015) BindingDB Entry DOI: 10.7270/Q2WQ02JX
					More data for this Ligand-Target Pair