BindingDB PrimarySearch

BDBM164883 US9067888, 33

SMILES: COc1cc(F)ccc1-c1ccnc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)c1

InChI Key: InChIKey=QNWXRLPZIFMTBK-DOTOQJQBSA-N

Data: 15 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 164883
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	94	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...				US Patent US9067888 (2015) BindingDB Entry DOI: 10.7270/Q2CR5S4T
AstraZeneca AB US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars		n/a	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Cyclin-dependent kinase 3 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	219	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...				US Patent US9067888 (2015) BindingDB Entry DOI: 10.7270/Q2CR5S4T
AstraZeneca AB US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.08E+3	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...				US Patent US9067888 (2015) BindingDB Entry DOI: 10.7270/Q2CR5S4T
AstraZeneca AB US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...				US Patent US9067888 (2015) BindingDB Entry DOI: 10.7270/Q2CR5S4T
AstraZeneca AB US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...				US Patent US9067888 (2015) BindingDB Entry DOI: 10.7270/Q2CR5S4T
AstraZeneca AB US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...				US Patent US9067888 (2015) BindingDB Entry DOI: 10.7270/Q2CR5S4T
AstraZeneca AB US Patent					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	160	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...				US Patent US9067888 (2015) BindingDB Entry DOI: 10.7270/Q2CR5S4T
AstraZeneca AB US Patent					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	903	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...				US Patent US9067888 (2015) BindingDB Entry DOI: 10.7270/Q2CR5S4T
AstraZeneca AB US Patent					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...				US Patent US9067888 (2015) BindingDB Entry DOI: 10.7270/Q2CR5S4T
AstraZeneca AB US Patent					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Inhibition of CDK9/cyclin T1 (unknown origin) using cdk7tide peptide as substrate				J Med Chem 59: 8667-8684 (2016) Article DOI: 10.1021/acs.jmedchem.6b00150 BindingDB Entry DOI: 10.7270/Q2G73GP8
University of Nebraska Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-A1/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Inhibition of recombinant human His/GST-tagged CDK2/Cyclin A expressed in baculovirus infected Sf9 cells using Histone H1 as substrate after 80 mins ...				J Med Chem 59: 8667-8684 (2016) Article DOI: 10.1021/acs.jmedchem.6b00150 BindingDB Entry DOI: 10.7270/Q2G73GP8
University of Nebraska Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Inhibition of recombinant human His/GST-tagged CDK5/p35 expressed in baculovirus infected Sf9 insect cells using Rb-CTF as substrate after 80 mins in...				J Med Chem 59: 8667-8684 (2016) Article DOI: 10.1021/acs.jmedchem.6b00150 BindingDB Entry DOI: 10.7270/Q2G73GP8
University of Nebraska Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Inhibition of recombinant human CDK1/cyclin B expressed in baculovirus infected Sf9 insect cells after 80 mins in presence of [33P]ATP by microbeta s...				J Med Chem 59: 8667-8684 (2016) Article DOI: 10.1021/acs.jmedchem.6b00150 BindingDB Entry DOI: 10.7270/Q2G73GP8
University of Nebraska Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 3/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Inhibition of recombinant human CDK3/cyclin E expressed in baculovirus infected Sf9 insect cells after 80 mins in presence of [33P]ATP by microbeta s...				J Med Chem 59: 8667-8684 (2016) Article DOI: 10.1021/acs.jmedchem.6b00150 BindingDB Entry DOI: 10.7270/Q2G73GP8
University of Nebraska Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars		n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars		n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM164883 (US9067888, 33) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	168	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...				US Patent US9067888 (2015) BindingDB Entry DOI: 10.7270/Q2CR5S4T
AstraZeneca AB US Patent					More data for this Ligand-Target Pair