BDBM164927 US10166239, Ex. 3-35-1::US9067914, Ex. 3-35-1

SMILES: COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cn1

InChI Key: InChIKey=QHFNVZMOKIFBBE-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 164927   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM164927 (US10166239, Ex. 3-35-1 | US9067914, Ex. 3-35-1) Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cn1 Show InChI InChI=1S/C25H25N7O3/c1-31-14-19(12-29-31)18-9-20-24(28-11-18)32(25(26)30-20)13-16-4-6-21(22(8-16)33-2)35-15-17-5-7-23(34-3)27-10-17/h4-12,14H,13,15H2,1-3H3,(H2,26,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.5	25
Genzyme Corporation US Patent					Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...				US Patent US9067914 (2015) BindingDB Entry DOI: 10.7270/Q28051CB
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM164927 (US10166239, Ex. 3-35-1 | US9067914, Ex. 3-35-1) Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cn1 Show InChI InChI=1S/C25H25N7O3/c1-31-14-19(12-29-31)18-9-20-24(28-11-18)32(25(26)30-20)13-16-4-6-21(22(8-16)33-2)35-15-17-5-7-23(34-3)27-10-17/h4-12,14H,13,15H2,1-3H3,(H2,26,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.5	25
Genzyme Corporation US Patent					Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...				US Patent US9067914 (2015) BindingDB Entry DOI: 10.7270/Q28051CB
					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM164927 (US10166239, Ex. 3-35-1 | US9067914, Ex. 3-35-1) Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cn1 Show InChI InChI=1S/C25H25N7O3/c1-31-14-19(12-29-31)18-9-20-24(28-11-18)32(25(26)30-20)13-16-4-6-21(22(8-16)33-2)35-15-17-5-7-23(34-3)27-10-17/h4-12,14H,13,15H2,1-3H3,(H2,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	25
Genzyme Corporation US Patent					Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...				US Patent US9067914 (2015) BindingDB Entry DOI: 10.7270/Q28051CB
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM164927 (US10166239, Ex. 3-35-1 | US9067914, Ex. 3-35-1) Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cn1 Show InChI InChI=1S/C25H25N7O3/c1-31-14-19(12-29-31)18-9-20-24(28-11-18)32(25(26)30-20)13-16-4-6-21(22(8-16)33-2)35-15-17-5-7-23(34-3)27-10-17/h4-12,14H,13,15H2,1-3H3,(H2,26,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Genzyme Corporation US Patent					Assay Description In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...				US Patent US10166239 (2019) BindingDB Entry DOI: 10.7270/Q2WW7KSN
					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM164927 (US10166239, Ex. 3-35-1 | US9067914, Ex. 3-35-1) Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cn1 Show InChI InChI=1S/C25H25N7O3/c1-31-14-19(12-29-31)18-9-20-24(28-11-18)32(25(26)30-20)13-16-4-6-21(22(8-16)33-2)35-15-17-5-7-23(34-3)27-10-17/h4-12,14H,13,15H2,1-3H3,(H2,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
GENZYME CORPORATION US Patent					Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...				US Patent US9611265 (2017) BindingDB Entry DOI: 10.7270/Q2S184KD
					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM164927 (US10166239, Ex. 3-35-1 | US9067914, Ex. 3-35-1) Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cn1 Show InChI InChI=1S/C25H25N7O3/c1-31-14-19(12-29-31)18-9-20-24(28-11-18)32(25(26)30-20)13-16-4-6-21(22(8-16)33-2)35-15-17-5-7-23(34-3)27-10-17/h4-12,14H,13,15H2,1-3H3,(H2,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Genzyme Corporation US Patent					Assay Description In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...				US Patent US10166239 (2019) BindingDB Entry DOI: 10.7270/Q2WW7KSN
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM164927 (US10166239, Ex. 3-35-1 | US9067914, Ex. 3-35-1) Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cn1 Show InChI InChI=1S/C25H25N7O3/c1-31-14-19(12-29-31)18-9-20-24(28-11-18)32(25(26)30-20)13-16-4-6-21(22(8-16)33-2)35-15-17-5-7-23(34-3)27-10-17/h4-12,14H,13,15H2,1-3H3,(H2,26,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
GENZYME CORPORATION US Patent					Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...				US Patent US9611265 (2017) BindingDB Entry DOI: 10.7270/Q2S184KD
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM164927 (US10166239, Ex. 3-35-1 | US9067914, Ex. 3-35-1) Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cn1 Show InChI InChI=1S/C25H25N7O3/c1-31-14-19(12-29-31)18-9-20-24(28-11-18)32(25(26)30-20)13-16-4-6-21(22(8-16)33-2)35-15-17-5-7-23(34-3)27-10-17/h4-12,14H,13,15H2,1-3H3,(H2,26,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
GENZYME CORPORATION US Patent					Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...				US Patent US9611265 (2017) BindingDB Entry DOI: 10.7270/Q2S184KD
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM164927 (US10166239, Ex. 3-35-1 | US9067914, Ex. 3-35-1) Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cn1 Show InChI InChI=1S/C25H25N7O3/c1-31-14-19(12-29-31)18-9-20-24(28-11-18)32(25(26)30-20)13-16-4-6-21(22(8-16)33-2)35-15-17-5-7-23(34-3)27-10-17/h4-12,14H,13,15H2,1-3H3,(H2,26,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Genzyme Corporation US Patent					Assay Description In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...				US Patent US10166239 (2019) BindingDB Entry DOI: 10.7270/Q2WW7KSN
					More data for this Ligand-Target Pair