BDBM16526 2-amino-N-{3-[(2-chlorophenyl)[1-(2-chlorophenyl)-6-oxo-1,6-dihydropyridazin-3-yl]amino]propyl}acetamide::2-arylpyridazin-3-one, 32
SMILES: NCC(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl
InChI Key: InChIKey=YQQSWNABYSVERP-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MAP Kinase p38 beta (Mus musculus (mouse)) | BDBM16526 (2-amino-N-{3-[(2-chlorophenyl)[1-(2-chlorophenyl)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea... | Bioorg Med Chem Lett 16: 5809-13 (2006) Article DOI: 10.1016/j.bmcl.2006.08.074 BindingDB Entry DOI: 10.7270/Q28P5XSC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase p38 (Mus musculus (mouse)) | BDBM16526 (2-amino-N-{3-[(2-chlorophenyl)[1-(2-chlorophenyl)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.0 | 30 |
Merck Research Laboratories | Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea... | Bioorg Med Chem Lett 16: 5809-13 (2006) Article DOI: 10.1016/j.bmcl.2006.08.074 BindingDB Entry DOI: 10.7270/Q28P5XSC | |||||||||||
More data for this Ligand-Target Pair |