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BDBM16527 2-arylpyridazin-3-one, 33::N-{3-[(2-chlorophenyl)[1-(2-chlorophenyl)-6-oxo-1,6-dihydropyridazin-3-yl]amino]propyl}-2-(methylamino)acetamide

SMILES: CNCC(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl

InChI Key: InChIKey=IWYYBVHHQRNVMT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16527   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP Kinase p38 beta


(Mus musculus (mouse))
BDBM16527
PNG
(2-arylpyridazin-3-one, 33 | N-{3-[(2-chlorophenyl)...)
Show SMILES CNCC(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl
Show InChI InChI=1S/C22H23Cl2N5O2/c1-25-15-21(30)26-13-6-14-28(18-9-4-2-7-16(18)23)20-11-12-22(31)29(27-20)19-10-5-3-8-17(19)24/h2-5,7-12,25H,6,13-15H2,1H3,(H,26,30)
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...


Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM16527
PNG
(2-arylpyridazin-3-one, 33 | N-{3-[(2-chlorophenyl)...)
Show SMILES CNCC(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl
Show InChI InChI=1S/C22H23Cl2N5O2/c1-25-15-21(30)26-13-6-14-28(18-9-4-2-7-16(18)23)20-11-12-22(31)29(27-20)19-10-5-3-8-17(19)24/h2-5,7-12,25H,6,13-15H2,1H3,(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 35n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...


Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair