BDBM16527 2-arylpyridazin-3-one, 33::N-{3-[(2-chlorophenyl)[1-(2-chlorophenyl)-6-oxo-1,6-dihydropyridazin-3-yl]amino]propyl}-2-(methylamino)acetamide

SMILES: CNCC(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl

InChI Key: InChIKey=IWYYBVHHQRNVMT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16527   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16527 (2-arylpyridazin-3-one, 33 | N-{3-[(2-chlorophenyl)...) Show SMILES CNCC(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl Show InChI InChI=1S/C22H23Cl2N5O2/c1-25-15-21(30)26-13-6-14-28(18-9-4-2-7-16(18)23)20-11-12-22(31)29(27-20)19-10-5-3-8-17(19)24/h2-5,7-12,25H,6,13-15H2,1H3,(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006) Article DOI: 10.1016/j.bmcl.2006.08.074 BindingDB Entry DOI: 10.7270/Q28P5XSC
					More data for this Ligand-Target Pair
MAP kinase p38 (Mus musculus (mouse))	BDBM16527 (2-arylpyridazin-3-one, 33 | N-{3-[(2-chlorophenyl)...) Show SMILES CNCC(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl Show InChI InChI=1S/C22H23Cl2N5O2/c1-25-15-21(30)26-13-6-14-28(18-9-4-2-7-16(18)23)20-11-12-22(31)29(27-20)19-10-5-3-8-17(19)24/h2-5,7-12,25H,6,13-15H2,1H3,(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	7.0	30
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006) Article DOI: 10.1016/j.bmcl.2006.08.074 BindingDB Entry DOI: 10.7270/Q28P5XSC
					More data for this Ligand-Target Pair