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BDBM16535 (3E)-5-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-3-(furan-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one::(S)-5-(5-(2-Amino-3-phenylpropoxy)pyridin-3-yl)-3-(furan-2-ylmethylene)indolin-2-one::oxindole-pyridine, 36

SMILES: N[C@H](COc1cncc(c1)-c1ccc2NC(=O)\C(=C\c3ccco3)c2c1)Cc1ccccc1

InChI Key: InChIKey=RHOXUCVDAMLMFG-NFCNUSAFSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16535   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16535
PNG
((3E)-5-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc2NC(=O)\C(=C\c3ccco3)c2c1)Cc1ccccc1 |r|
Show InChI InChI=1S/C27H23N3O3/c28-21(11-18-5-2-1-3-6-18)17-33-23-12-20(15-29-16-23)19-8-9-26-24(13-19)25(27(31)30-26)14-22-7-4-10-32-22/h1-10,12-16,21H,11,17,28H2,(H,30,31)/b25-14+/t21-/m0/s1
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.40n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
More data for this
Ligand-Target Pair