BDBM16537 (2S)-1-(2,3-difluorophenyl)-3-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]oxy}propan-2-amine::5-{5-[(2S)-2-amino-3-(2,3-difluorophenyl)propoxy]pyridin-3-yl}-3-methyl-1H-indazole::indazole-pyridine, 13b

SMILES: Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(F)c2F)c1

InChI Key: InChIKey=ZNQFWMICKJTIBV-KRWDZBQOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16537   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine))	BDBM16537 ((2S)-1-(2,3-difluorophenyl)-3-{[5-(3-methyl-1H-ind...) Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(F)c2F)c1 |r| Show InChI InChI=1S/C22H20F2N4O/c1-13-19-9-14(5-6-21(19)28-27-13)16-8-18(11-26-10-16)29-12-17(25)7-15-3-2-4-20(23)22(15)24/h2-6,8-11,17H,7,12,25H2,1H3,(H,27,28)/t17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...				J Med Chem 50: 2990-3003 (2007) Article DOI: 10.1021/jm0701019 BindingDB Entry DOI: 10.7270/Q24X562F
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM16537 ((2S)-1-(2,3-difluorophenyl)-3-{[5-(3-methyl-1H-ind...) Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(F)c2F)c1 |r| Show InChI InChI=1S/C22H20F2N4O/c1-13-19-9-14(5-6-21(19)28-27-13)16-8-18(11-26-10-16)29-12-17(25)7-15-3-2-4-20(23)22(15)24/h2-6,8-11,17H,7,12,25H2,1H3,(H,27,28)/t17-/m0/s1	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.5	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				J Med Chem 50: 2990-3003 (2007) Article DOI: 10.1021/jm0701019 BindingDB Entry DOI: 10.7270/Q24X562F
					More data for this Ligand-Target Pair