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BDBM16550 (2S)-1-(3-fluoro-4-chlorophenyl)-3-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]oxy}propan-2-amine::5-{5-[(2S)-2-amino-3-(4-chloro-3-fluorophenyl)propoxy]pyridin-3-yl}-3-methyl-1H-indazole::indazole-pyridine, 13o

SMILES: Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(Cl)c(F)c2)c1

InChI Key: InChIKey=VUDFVJOMOPUVQE-KRWDZBQOSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16550   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16550
PNG
((2S)-1-(3-fluoro-4-chlorophenyl)-3-{[5-(3-methyl-1...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(Cl)c(F)c2)c1 |r|
Show InChI InChI=1S/C22H20ClFN4O/c1-13-19-9-15(3-5-22(19)28-27-13)16-8-18(11-26-10-16)29-12-17(25)6-14-2-4-20(23)21(24)7-14/h2-5,7-11,17H,6,12,25H2,1H3,(H,27,28)/t17-/m0/s1
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.60n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
More data for this
Ligand-Target Pair