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SMILES: Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(F)cc2C)c1

InChI Key: InChIKey=AMRMQCBFQCECAQ-FQEVSTJZSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16560   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAC-alpha serine/threonine-protein kinase [139-480,S378A,S381A,T450D,S473D]


(Homo sapiens (Human))		BDBM16560
PNG
((2S)-1-(2-methyl-4-fluorophenyl)-3-{[5-(3-methyl-1...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(F)cc2C)c1 |r|
Show InChI InChI=1S/C23H23FN4O/c1-14-7-19(24)5-3-16(14)8-20(25)13-29-21-9-18(11-26-12-21)17-4-6-23-22(10-17)15(2)27-28-23/h3-7,9-12,20H,8,13,25H2,1-2H3,(H,27,28)/t20-/m0/s1
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Similars
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...

J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair