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BDBM16563 (2S)-1-(5-fluoro-2-methoxyphenyl)-3-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]oxy}propan-2-amine::5-{5-[(2S)-2-amino-3-(5-fluoro-2-methoxyphenyl)propoxy]pyridin-3-yl}-3-methyl-1H-indazole::indazole-pyridine, 13ab

SMILES: COc1ccc(F)cc1C[C@H](N)COc1cncc(c1)-c1ccc2[nH]nc(C)c2c1

InChI Key: InChIKey=LDEDKSSJQNWMBW-IBGZPJMESA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16563   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16563
PNG
((2S)-1-(5-fluoro-2-methoxyphenyl)-3-{[5-(3-methyl-...)
Show SMILES COc1ccc(F)cc1C[C@H](N)COc1cncc(c1)-c1ccc2[nH]nc(C)c2c1 |r|
Show InChI InChI=1S/C23H23FN4O2/c1-14-21-10-15(3-5-22(21)28-27-14)17-9-20(12-26-11-17)30-13-19(25)8-16-7-18(24)4-6-23(16)29-2/h3-7,9-12,19H,8,13,25H2,1-2H3,(H,27,28)/t19-/m0/s1
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.70n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair