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BDBM16572 (2S)-1-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]oxy}-3-[2-(trifluoromethoxy)phenyl]propan-2-amine::5-{5-[(2S)-2-amino-3-[2-(trifluoromethoxy)phenyl]propoxy]pyridin-3-yl}-3-methyl-1H-indazole::indazole-pyridine, 13ak

SMILES: Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2OC(F)(F)F)c1

InChI Key: InChIKey=UZWLWPWRMAJLSK-SFHVURJKSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16572   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16572
PNG
((2S)-1-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2OC(F)(F)F)c1 |r|
Show InChI InChI=1S/C23H21F3N4O2/c1-14-20-10-15(6-7-21(20)30-29-14)17-9-19(12-28-11-17)31-13-18(27)8-16-4-2-3-5-22(16)32-23(24,25)26/h2-7,9-12,18H,8,13,27H2,1H3,(H,29,30)/t18-/m0/s1
PDB
MMDB

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PC cid
PC sid
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Patents

Article
PubMed
n/an/a 15.3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair