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SMILES: Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(OCC3CCNCC3)c2)c1

InChI Key: InChIKey=ONYHXSRUAIWPON-DEOSSOPVSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16581   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAC-alpha serine/threonine-protein kinase [139-480,S378A,S381A,T450D,S473D]


(Homo sapiens (Human))		BDBM16581
PNG
(5-{5-[(2S)-2-amino-3-[3-(piperidin-4-ylmethoxy)phe...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(OCC3CCNCC3)c2)c1 |r|
Show InChI InChI=1S/C28H33N5O2/c1-19-27-14-22(5-6-28(27)33-32-19)23-13-26(16-31-15-23)35-18-24(29)11-21-3-2-4-25(12-21)34-17-20-7-9-30-10-8-20/h2-6,12-16,20,24,30H,7-11,17-18,29H2,1H3,(H,32,33)/t24-/m0/s1
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MMDB

UniProtKB/SwissProt

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PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.80n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...

J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair