BDBM167058 US9073876, 144::US9732093, Compound 144

SMILES: Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2ccnc(n2)-c2ccccc2)c1F

InChI Key: InChIKey=BTOUGZKPQYKQDV-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 167058   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM167058 (US9073876, 144 | US9732093, Compound 144) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2ccnc(n2)-c2ccccc2)c1F Show InChI InChI=1S/C24H20FN5O/c25-22-18(19-13-29-20(26)14-28-19)10-9-17(15-7-4-8-15)23(22)31-21-11-12-27-24(30-21)16-5-2-1-3-6-16/h1-3,5-6,9-15H,4,7-8H2,(H2,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9073876 (2015) BindingDB Entry DOI: 10.7270/Q28S4NPC
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167058 (US9073876, 144 | US9732093, Compound 144) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2ccnc(n2)-c2ccccc2)c1F Show InChI InChI=1S/C24H20FN5O/c25-22-18(19-13-29-20(26)14-28-19)10-9-17(15-7-4-8-15)23(22)31-21-11-12-27-24(30-21)16-5-2-1-3-6-16/h1-3,5-6,9-15H,4,7-8H2,(H2,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167058 (US9073876, 144 | US9732093, Compound 144) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2ccnc(n2)-c2ccccc2)c1F Show InChI InChI=1S/C24H20FN5O/c25-22-18(19-13-29-20(26)14-28-19)10-9-17(15-7-4-8-15)23(22)31-21-11-12-27-24(30-21)16-5-2-1-3-6-16/h1-3,5-6,9-15H,4,7-8H2,(H2,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair