BDBM167083 US9073876, 168::US9732093, Compound 168

SMILES: CC(C)c1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)nc2)nc(N)n1

InChI Key: InChIKey=OCPFHACBHYOIES-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 167083   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM167083 (US9073876, 168 | US9732093, Compound 168) Show SMILES CC(C)c1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)nc2)nc(N)n1 Show InChI InChI=1S/C21H23FN6O/c1-11(2)16-8-17(28-21(24)27-16)29-19-15(12-4-3-5-12)7-6-14(18(19)22)13-9-25-20(23)26-10-13/h6-12H,3-5H2,1-2H3,(H2,23,25,26)(H2,24,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9073876 (2015) BindingDB Entry DOI: 10.7270/Q28S4NPC
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167083 (US9073876, 168 | US9732093, Compound 168) Show SMILES CC(C)c1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)nc2)nc(N)n1 Show InChI InChI=1S/C21H23FN6O/c1-11(2)16-8-17(28-21(24)27-16)29-19-15(12-4-3-5-12)7-6-14(18(19)22)13-9-25-20(23)26-10-13/h6-12H,3-5H2,1-2H3,(H2,23,25,26)(H2,24,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167083 (US9073876, 168 | US9732093, Compound 168) Show SMILES CC(C)c1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)nc2)nc(N)n1 Show InChI InChI=1S/C21H23FN6O/c1-11(2)16-8-17(28-21(24)27-16)29-19-15(12-4-3-5-12)7-6-14(18(19)22)13-9-25-20(23)26-10-13/h6-12H,3-5H2,1-2H3,(H2,23,25,26)(H2,24,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair