BDBM167144 US9073876, 226::US9732093, Compound 226

SMILES: Nc1ccnc(Oc2c(F)c(ccc2C2CCC2)-c2cnc3NCCOc3c2)n1

InChI Key: InChIKey=CCDKWBHLJMWSJM-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 167144   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM167144 (US9073876, 226 | US9732093, Compound 226) Show SMILES Nc1ccnc(Oc2c(F)c(ccc2C2CCC2)-c2cnc3NCCOc3c2)n1 Show InChI InChI=1S/C21H20FN5O2/c22-18-14(13-10-16-20(26-11-13)24-8-9-28-16)4-5-15(12-2-1-3-12)19(18)29-21-25-7-6-17(23)27-21/h4-7,10-12H,1-3,8-9H2,(H,24,26)(H2,23,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9073876 (2015) BindingDB Entry DOI: 10.7270/Q28S4NPC
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167144 (US9073876, 226 | US9732093, Compound 226) Show SMILES Nc1ccnc(Oc2c(F)c(ccc2C2CCC2)-c2cnc3NCCOc3c2)n1 Show InChI InChI=1S/C21H20FN5O2/c22-18-14(13-10-16-20(26-11-13)24-8-9-28-16)4-5-15(12-2-1-3-12)19(18)29-21-25-7-6-17(23)27-21/h4-7,10-12H,1-3,8-9H2,(H,24,26)(H2,23,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167144 (US9073876, 226 | US9732093, Compound 226) Show SMILES Nc1ccnc(Oc2c(F)c(ccc2C2CCC2)-c2cnc3NCCOc3c2)n1 Show InChI InChI=1S/C21H20FN5O2/c22-18-14(13-10-16-20(26-11-13)24-8-9-28-16)4-5-15(12-2-1-3-12)19(18)29-21-25-7-6-17(23)27-21/h4-7,10-12H,1-3,8-9H2,(H,24,26)(H2,23,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair