BDBM16755 Acylguanidine, 10d::N-[(1Z)-amino[(3-hydroxypropyl)amino]methylidene]-2-[2-(2-chlorophenyl)-5-(4-propoxyphenyl)-1H-pyrrol-1-yl]acetamide
SMILES: CCCOc1ccc(cc1)-c1ccc(-c2ccccc2Cl)n1CC(=O)NC(=N)NCCCO
InChI Key: InChIKey=FDBNUXAMAFEWOP-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (Homo sapiens (Human)) | BDBM16755 (Acylguanidine, 10d | N-[(1Z)-amino[(3-hydroxypropy...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | 4.5 | 22 |
Wyeth Research | Assay Description A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o... | J Med Chem 49: 6158-61 (2006) Article DOI: 10.1021/jm0607451 BindingDB Entry DOI: 10.7270/Q2M043NG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 2 (Homo sapiens (Human)) | BDBM16755 (Acylguanidine, 10d | N-[(1Z)-amino[(3-hydroxypropy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 340 | n/a | n/a | n/a | n/a | 4.5 | 22 |
Wyeth Research | Assay Description A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o... | J Med Chem 49: 6158-61 (2006) Article DOI: 10.1021/jm0607451 BindingDB Entry DOI: 10.7270/Q2M043NG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM16755 (Acylguanidine, 10d | N-[(1Z)-amino[(3-hydroxypropy...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 121 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of BACE1 | Bioorg Med Chem Lett 18: 767-71 (2008) Article DOI: 10.1016/j.bmcl.2007.11.043 BindingDB Entry DOI: 10.7270/Q27S7PK8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin (Homo sapiens (Human)) | BDBM16755 (Acylguanidine, 10d | N-[(1Z)-amino[(3-hydroxypropy...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 4.5 | 22 |
Wyeth Research | Assay Description A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o... | J Med Chem 49: 6158-61 (2006) Article DOI: 10.1021/jm0607451 BindingDB Entry DOI: 10.7270/Q2M043NG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM16755 (Acylguanidine, 10d | N-[(1Z)-amino[(3-hydroxypropy...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of human BACE1 by FRET | J Med Chem 52: 6314-23 (2009) Article DOI: 10.1021/jm9006752 BindingDB Entry DOI: 10.7270/Q2Z89CHR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin D (Homo sapiens (Human)) | BDBM16755 (Acylguanidine, 10d | N-[(1Z)-amino[(3-hydroxypropy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | 4.5 | 22 |
Wyeth Research | Assay Description A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o... | J Med Chem 49: 6158-61 (2006) Article DOI: 10.1021/jm0607451 BindingDB Entry DOI: 10.7270/Q2M043NG | |||||||||||
More data for this Ligand-Target Pair |