BDBM167859 US9073922, 356

SMILES: CNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cncc(OCc2cccc(F)c2)n1

InChI Key: InChIKey=KXXLFHRMLJDFGC-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 167859   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM167859 (US9073922, 356) Show SMILES CNC(=O)N1CCC(=CC1)c1cc2c(ccnc2[nH]1)-c1cncc(OCc2cccc(F)c2)n1 |c:7| Show InChI InChI=1S/C25H23FN6O2/c1-27-25(33)32-9-6-17(7-10-32)21-12-20-19(5-8-29-24(20)31-21)22-13-28-14-23(30-22)34-15-16-3-2-4-18(26)11-16/h2-6,8,11-14H,7,9-10,15H2,1H3,(H,27,33)(H,29,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie, Inc. US Patent					Assay Description CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...				US Patent US9073922 (2015) BindingDB Entry DOI: 10.7270/Q2CJ8C78
					More data for this Ligand-Target Pair