BDBM167944 1,5-Dimethyl-4-(3-methyl-1-phenyl-5-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)-2-phenyl-1H-pyrazol-3(2H)-one (27)
SMILES: Cc1nn(-c2ccccc2)c2nc(-c3c(C)n(C)n(-c4ccccc4)c3=O)c(cc12)S(=O)(=O)c1ccccc1
InChI Key: InChIKey=IOIQEDWYVQCGLH-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase-IV (DDP-4) (Homo sapiens (Human)) | BDBM167944 (1,5-Dimethyl-4-(3-methyl-1-phenyl-5-(phenylsulfony...) | PDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >50 | n/a | n/a | n/a | n/a | n/a | 25 |
Cairo University | Assay Description A 200-µL reaction system containing DPP-IV (Sigma), a test compound, and 25 mmol/L HEPES buffer (containing 140 mmol/L NaCl, 1% BSA, and 80 mmol/L Mg... | Chem Biol Drug Des 86: 1292-303 (2015) Article DOI: 10.1111/cbdd.12593 BindingDB Entry DOI: 10.7270/Q2M32THN | |||||||||||
More data for this Ligand-Target Pair |