BDBM167950 1-(4-(4-Nitrophenyl)piperazin-1-yl)-3-(quinazolin-4-yloxy)propan-2-ol (3f)

SMILES: OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(cc1)[N+]([O-])=O

InChI Key: InChIKey=LDYXRYLRGPOXCN-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 167950   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM167950 (1-(4-(4-Nitrophenyl)piperazin-1-yl)-3-(quinazolin-...) Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(cc1)[N+]([O-])=O Show InChI InChI=1S/C21H23N5O4/c27-18(14-30-21-19-3-1-2-4-20(19)22-15-23-21)13-24-9-11-25(12-10-24)16-5-7-17(8-6-16)26(28)29/h1-8,15,18,27H,9-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16.5	n/a	n/a	n/a	n/a	7.2	25
Nanjing University					Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...				Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM167950 (1-(4-(4-Nitrophenyl)piperazin-1-yl)-3-(quinazolin-...) Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(cc1)[N+]([O-])=O Show InChI InChI=1S/C21H23N5O4/c27-18(14-30-21-19-3-1-2-4-20(19)22-15-23-21)13-24-9-11-25(12-10-24)16-5-7-17(8-6-16)26(28)29/h1-8,15,18,27H,9-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	109	n/a	n/a	n/a	n/a	7.2	25
Nanjing University					Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...				Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR
					More data for this Ligand-Target Pair
Fibroblast growth factor 2 (Homo sapiens (Human))	BDBM167950 (1-(4-(4-Nitrophenyl)piperazin-1-yl)-3-(quinazolin-...) Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(cc1)[N+]([O-])=O Show InChI InChI=1S/C21H23N5O4/c27-18(14-30-21-19-3-1-2-4-20(19)22-15-23-21)13-24-9-11-25(12-10-24)16-5-7-17(8-6-16)26(28)29/h1-8,15,18,27H,9-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	248	n/a	n/a	n/a	n/a	7.2	25
Nanjing University					Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...				Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM167950 (1-(4-(4-Nitrophenyl)piperazin-1-yl)-3-(quinazolin-...) Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(cc1)[N+]([O-])=O Show InChI InChI=1S/C21H23N5O4/c27-18(14-30-21-19-3-1-2-4-20(19)22-15-23-21)13-24-9-11-25(12-10-24)16-5-7-17(8-6-16)26(28)29/h1-8,15,18,27H,9-14H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	382	n/a	n/a	n/a	n/a	7.2	25
Nanjing University					Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...				Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR
					More data for this Ligand-Target Pair