BDBM167958 1-(4-Benzylpiperazin-1-yl)-3-(quinazolin-4-yloxy)propan-2-ol (3n)

SMILES: OC(COc1ncnc2ccccc12)CN1CCN(Cc2ccccc2)CC1

InChI Key: InChIKey=GJRDMRRBRLWIMA-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 167958   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM167958 (1-(4-Benzylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...) Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(Cc2ccccc2)CC1 Show InChI InChI=1S/C22H26N4O2/c27-19(16-28-22-20-8-4-5-9-21(20)23-17-24-22)15-26-12-10-25(11-13-26)14-18-6-2-1-3-7-18/h1-9,17,19,27H,10-16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52.2	n/a	n/a	n/a	n/a	7.2	25
Nanjing University					Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...				Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM167958 (1-(4-Benzylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...) Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(Cc2ccccc2)CC1 Show InChI InChI=1S/C22H26N4O2/c27-19(16-28-22-20-8-4-5-9-21(20)23-17-24-22)15-26-12-10-25(11-13-26)14-18-6-2-1-3-7-18/h1-9,17,19,27H,10-16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	219	n/a	n/a	n/a	n/a	7.2	25
Nanjing University					Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...				Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR
					More data for this Ligand-Target Pair
Fibroblast growth factor 2 (Homo sapiens (Human))	BDBM167958 (1-(4-Benzylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...) Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(Cc2ccccc2)CC1 Show InChI InChI=1S/C22H26N4O2/c27-19(16-28-22-20-8-4-5-9-21(20)23-17-24-22)15-26-12-10-25(11-13-26)14-18-6-2-1-3-7-18/h1-9,17,19,27H,10-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	444	n/a	n/a	n/a	n/a	7.2	25
Nanjing University					Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...				Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM167958 (1-(4-Benzylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...) Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(Cc2ccccc2)CC1 Show InChI InChI=1S/C22H26N4O2/c27-19(16-28-22-20-8-4-5-9-21(20)23-17-24-22)15-26-12-10-25(11-13-26)14-18-6-2-1-3-7-18/h1-9,17,19,27H,10-16H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	435	n/a	n/a	n/a	n/a	7.2	25
Nanjing University					Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...				Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR
					More data for this Ligand-Target Pair