BDBM167959 1-(4-Methylpiperazin-1-yl)-3-(quinazolin-4-yloxy)propan-2-ol (3o)
SMILES: CN1CCN(CC(O)COc2ncnc3ccccc23)CC1
InChI Key: InChIKey=NZLWNFZAMQUOSN-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM167959 (1-(4-Methylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 59.3 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Nanjing University | Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r... | Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM167959 (1-(4-Methylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 224 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Nanjing University | Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r... | Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor 2 (Homo sapiens (Human)) | BDBM167959 (1-(4-Methylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 419 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Nanjing University | Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r... | Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM167959 (1-(4-Methylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 474 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Nanjing University | Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r... | Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR | |||||||||||
More data for this Ligand-Target Pair |