BDBM168301 US9669031, 127 6′-((1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-8′-chloro-2′H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione (Cpd. No. 127)::US9669031, 145 6′-((1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-8′-chloro-2′H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione (Cpd. No. 145)

SMILES: Clc1cc(Nc2ncnc3[nH]ncc23)c(=O)n2c1C(=O)NC21CCCCC1

InChI Key: InChIKey=RWALTXNCWCAKGV-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 168301   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM168301 (US9669031, 127 6′-((1H-pyrazolo[3,4-d]pyrimi...) Show SMILES Clc1cc(Nc2ncnc3[nH]ncc23)c(=O)n2c1C(=O)NC21CCCCC1 Show InChI InChI=1S/C17H16ClN7O2/c18-10-6-11(22-13-9-7-21-24-14(9)20-8-19-13)16(27)25-12(10)15(26)23-17(25)4-2-1-3-5-17/h6-8H,1-5H2,(H,23,26)(H2,19,20,21,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
eFFECTOR THERAPEUTICS, INC. US Patent					Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...				US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM168301 (US9669031, 127 6′-((1H-pyrazolo[3,4-d]pyrimi...) Show SMILES Clc1cc(Nc2ncnc3[nH]ncc23)c(=O)n2c1C(=O)NC21CCCCC1 Show InChI InChI=1S/C17H16ClN7O2/c18-10-6-11(22-13-9-7-21-24-14(9)20-8-19-13)16(27)25-12(10)15(26)23-17(25)4-2-1-3-5-17/h6-8H,1-5H2,(H,23,26)(H2,19,20,21,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
eFFECTOR THERAPEUTICS, INC. US Patent					Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...				US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM168301 (US9669031, 127 6′-((1H-pyrazolo[3,4-d]pyrimi...) Show SMILES Clc1cc(Nc2ncnc3[nH]ncc23)c(=O)n2c1C(=O)NC21CCCCC1 Show InChI InChI=1S/C17H16ClN7O2/c18-10-6-11(22-13-9-7-21-24-14(9)20-8-19-13)16(27)25-12(10)15(26)23-17(25)4-2-1-3-5-17/h6-8H,1-5H2,(H,23,26)(H2,19,20,21,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
eFFECTOR THERAPEUTICS, INC. US Patent					Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...				US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM168301 (US9669031, 127 6′-((1H-pyrazolo[3,4-d]pyrimi...) Show SMILES Clc1cc(Nc2ncnc3[nH]ncc23)c(=O)n2c1C(=O)NC21CCCCC1 Show InChI InChI=1S/C17H16ClN7O2/c18-10-6-11(22-13-9-7-21-24-14(9)20-8-19-13)16(27)25-12(10)15(26)23-17(25)4-2-1-3-5-17/h6-8H,1-5H2,(H,23,26)(H2,19,20,21,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
eFFECTOR THERAPEUTICS, INC. US Patent					Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...				US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT
					More data for this Ligand-Target Pair