BDBM168308 US9669031, 142 4-((8′-chloro-1′,5′-dioxo-1′,5′-dihydro-2′H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridin]-6′-yl)amino)pyrimidine-5-carbonitrile (Cpd. No. 142)

SMILES: Clc1cc(Nc2ncncc2C#N)c(=O)n2c1C(=O)NC21CCCCC1

InChI Key: InChIKey=JTGDAAJGSXVAJB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 168308   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM168308 (US9669031, 142 4-((8′-chloro-1′,5̸...) Show SMILES Clc1cc(Nc2ncncc2C#N)c(=O)n2c1C(=O)NC21CCCCC1 Show InChI InChI=1S/C17H15ClN6O2/c18-11-6-12(22-14-10(7-19)8-20-9-21-14)16(26)24-13(11)15(25)23-17(24)4-2-1-3-5-17/h6,8-9H,1-5H2,(H,23,25)(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
eFFECTOR THERAPEUTICS, INC. US Patent					Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...				US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM168308 (US9669031, 142 4-((8′-chloro-1′,5̸...) Show SMILES Clc1cc(Nc2ncncc2C#N)c(=O)n2c1C(=O)NC21CCCCC1 Show InChI InChI=1S/C17H15ClN6O2/c18-11-6-12(22-14-10(7-19)8-20-9-21-14)16(26)24-13(11)15(25)23-17(24)4-2-1-3-5-17/h6,8-9H,1-5H2,(H,23,25)(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
eFFECTOR THERAPEUTICS, INC. US Patent					Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...				US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT
					More data for this Ligand-Target Pair