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SMILES: FC(F)(F)C1CCCCC11NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12

InChI Key: InChIKey=YGLZKYMIRSLUGB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 168342   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168342
PNG
(US9669031, 191 8′-chloro-6′-(pyrimidin...)
Show SMILES FC(F)(F)C1CCCCC11NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C17H15ClF3N5O2/c18-9-7-10(24-12-4-6-22-8-23-12)15(28)26-13(9)14(27)25-16(26)5-2-1-3-11(16)17(19,20)21/h4,6-8,11H,1-3,5H2,(H,25,27)(H,22,23,24)
PDB
MMDB

KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair