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SMILES: CN1CCC2(CC1)NC(=O)c1c(C)cc(Nc3cc(ncn3)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(=O)n21

InChI Key: InChIKey=JCVPTSUNQRSFSX-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 168367   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168367
PNG
(US9669031, 219 6-((6-aminopyrimidin-4-yl)amino)-1&...)
Show SMILES CN1CCC2(CC1)NC(=O)c1c(C)cc(Nc3cc(ncn3)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(=O)n21
Show InChI InChI=1S/C27H37N7O6/c1-16-13-17(22(36)34-20(16)21(35)31-27(34)9-11-32(8)12-10-27)30-18-14-19(29-15-28-18)33(23(37)39-25(2,3)4)24(38)40-26(5,6)7/h13-15H,9-12H2,1-8H3,(H,31,35)(H,28,29,30)
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MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair