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SMILES: COc1cncnc1Nc1cc(C)c2C(=O)NC3(CCN(CC(F)(F)F)CC3)n2c1=O

InChI Key: InChIKey=HZSXKMQIYPBWDE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 168380   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168380
PNG
(US9669031, 235 6-((5-methoxypyrimidin-4-yl)amino)-...)
Show SMILES COc1cncnc1Nc1cc(C)c2C(=O)NC3(CCN(CC(F)(F)F)CC3)n2c1=O
Show InChI InChI=1S/C19H21F3N6O3/c1-11-7-12(25-15-13(31-2)8-23-10-24-15)17(30)28-14(11)16(29)26-18(28)3-5-27(6-4-18)9-19(20,21)22/h7-8,10H,3-6,9H2,1-2H3,(H,26,29)(H,23,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair