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BDBM168436 US9675591, SKA-19

SMILES: Nc1nc2ccc(SC(F)(F)F)cc2s1

InChI Key: InChIKey=PBRVVEXJMLEKMJ-UHFFFAOYSA-N

Data: 9 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 168436   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Small conductance calcium-activated potassium channel protein 1 (KCa2.1)


(Homo sapiens (Human))
BDBM168436
PNG
(US9675591, SKA-19)
Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1
Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13)
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n/an/an/an/a>1.00E+5n/an/a7.3525



The Regents of the University of California

US Patent


Assay Description
All experiments were conducted at room temperature (22-24 C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...


US Patent US9675591 (2017)


BindingDB Entry DOI: 10.7270/Q26T0JSP
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (KCa2.2)


(Rattus norvegicus (Rat))
BDBM168436
PNG
(US9675591, SKA-19)
Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1
Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13)
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n/an/an/an/a 1.40E+4n/an/a7.3525



The Regents of the University of California

US Patent


Assay Description
All experiments were conducted at room temperature (22-24 C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...


US Patent US9675591 (2017)


BindingDB Entry DOI: 10.7270/Q26T0JSP
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM168436
PNG
(US9675591, SKA-19)
Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1
Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13)
PDB

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n/an/an/an/a 1.50E+4n/an/a7.3525



The Regents of the University of California

US Patent


Assay Description
All experiments were conducted at room temperature (22-24 C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...


US Patent US9675591 (2017)


BindingDB Entry DOI: 10.7270/Q26T0JSP
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM168436
PNG
(US9675591, SKA-19)
Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1
Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13)
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n/an/an/an/a 6.90E+3n/an/a7.3525



The Regents of the University of California

US Patent


Assay Description
All experiments were conducted at room temperature (22-24 C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...


US Patent US9675591 (2017)


BindingDB Entry DOI: 10.7270/Q26T0JSP
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv2.1 (Kv2.1)


(Homo sapiens (Human))
BDBM168436
PNG
(US9675591, SKA-19)
Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1
Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13)
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n/an/an/an/a 2.23E+4n/an/a7.3525



The Regents of the University of California

US Patent


Assay Description
All experiments were conducted at room temperature (22-24 C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...


US Patent US9675591 (2017)


BindingDB Entry DOI: 10.7270/Q26T0JSP
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3)


(Homo sapiens (Human))
BDBM168436
PNG
(US9675591, SKA-19)
Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1
Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13)
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n/an/an/an/a 2.20E+3n/an/a7.3525



The Regents of the University of California

US Patent


Assay Description
All experiments were conducted at room temperature (22-24 C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...


US Patent US9675591 (2017)


BindingDB Entry DOI: 10.7270/Q26T0JSP
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM168436
PNG
(US9675591, SKA-19)
Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1
Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13)
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n/an/an/an/a 4.50E+3n/an/a7.3525



The Regents of the University of California

US Patent


Assay Description
All experiments were conducted at room temperature (22-24 C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...


US Patent US9675591 (2017)


BindingDB Entry DOI: 10.7270/Q26T0JSP
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM168436
PNG
(US9675591, SKA-19)
Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1
Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13)
PDB

KEGG

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n/an/an/an/a 5.80E+3n/an/a7.3525



The Regents of the University of California

US Patent


Assay Description
All experiments were conducted at room temperature (22-24 C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...


US Patent US9675591 (2017)


BindingDB Entry DOI: 10.7270/Q26T0JSP
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM168436
PNG
(US9675591, SKA-19)
Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1
Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
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PC cid
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UniChem
US Patent
n/an/an/an/a 7.90E+3n/an/a7.3525



The Regents of the University of California

US Patent


Assay Description
All experiments were conducted at room temperature (22-24 C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...


US Patent US9675591 (2017)


BindingDB Entry DOI: 10.7270/Q26T0JSP
More data for this
Ligand-Target Pair