BDBM168992 US9079866, 393::US9745328, Compound 393::US9884878, Compound 393

SMILES: CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2NCCOc2c1

InChI Key: InChIKey=MKOLBGFWFWZGSN-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 168992   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM168992 (US9079866, 393 | US9745328, Compound 393 | US98848...) Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2NCCOc2c1 Show InChI InChI=1S/C23H24FN3O3S/c1-23(2,3)27-31(28,29)21-7-5-4-6-18(21)15-8-9-17(19(24)12-15)16-13-20-22(26-14-16)25-10-11-30-20/h4-9,12-14,27H,10-11H2,1-3H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9079866 (2015) BindingDB Entry DOI: 10.7270/Q2FF3R3Q
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168992 (US9079866, 393 | US9745328, Compound 393 | US98848...) Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2NCCOc2c1 Show InChI InChI=1S/C23H24FN3O3S/c1-23(2,3)27-31(28,29)21-7-5-4-6-18(21)15-8-9-17(19(24)12-15)16-13-20-22(26-14-16)25-10-11-30-20/h4-9,12-14,27H,10-11H2,1-3H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM168992 (US9079866, 393 | US9745328, Compound 393 | US98848...) Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2NCCOc2c1 Show InChI InChI=1S/C23H24FN3O3S/c1-23(2,3)27-31(28,29)21-7-5-4-6-18(21)15-8-9-17(19(24)12-15)16-13-20-22(26-14-16)25-10-11-30-20/h4-9,12-14,27H,10-11H2,1-3H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9884878 (2018) BindingDB Entry DOI: 10.7270/Q2R78H8P
					More data for this Ligand-Target Pair