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BDBM16939 (3Z)-5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}-3-(cyclopropylmethylidene)-2,3-dihydro-1H-indol-2-one::Z/E=1:1::oxindole pyridine, 11a

SMILES: N[C@H](COc1cncc(c1)-c1ccc2NC(=O)\C(=C/C3CC3)c2c1)Cc1c[nH]c2ccccc12

InChI Key: InChIKey=NCPIWDKRXYPPHJ-ZWJWCZNUSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16939   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16939
PNG
((3Z)-5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]p...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc2NC(=O)\C(=C/C3CC3)c2c1)Cc1c[nH]c2ccccc12 |r|
Show InChI InChI=1S/C28H26N4O2/c29-21(10-20-14-31-26-4-2-1-3-23(20)26)16-34-22-11-19(13-30-15-22)18-7-8-27-24(12-18)25(28(33)32-27)9-17-5-6-17/h1-4,7-9,11-15,17,21,31H,5-6,10,16,29H2,(H,32,33)/b25-9-/t21-/m0/s1
PDB
MMDB

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PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 3.30n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 3424-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.005
More data for this
Ligand-Target Pair