Found 17 hits for monomerid = 17015 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Macrophage colony-stimulating factor 1 receptor (aa 538-972)
() | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johnson & Johnson Pharmaceutical
| Assay Description The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e... |
J Biol Chem 282: 4085-93 (2007)
Article DOI: 10.1074/jbc.M608182200 BindingDB Entry DOI: 10.7270/Q2NK3C8N |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milano-Bicocca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cells |
Bioorg Med Chem 18: 1482-96 (2010)
Article DOI: 10.1016/j.bmc.2010.01.011 BindingDB Entry DOI: 10.7270/Q2B56KPQ |
More data for this Ligand-Target Pair | |
6His.FMS.538-922(FGFR)
(Human Sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johnson & Johnson Pharmaceutical
| Assay Description The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e... |
J Biol Chem 282: 4085-93 (2007)
Article DOI: 10.1074/jbc.M608182200 BindingDB Entry DOI: 10.7270/Q2NK3C8N |
More data for this Ligand-Target Pair | |
3-phosphoinositide dependent protein kinase-1
(Homo sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Berlex Biosciences
| Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub... |
Bioorg Med Chem Lett 17: 3814-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.071 BindingDB Entry DOI: 10.7270/Q25Q4TBB |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc.
Curated by ChEMBL
| Assay Description Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK). |
J Med Chem 41: 2588-603 (1998)
Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Mus musculus) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc.
Curated by ChEMBL
| Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK). |
J Med Chem 41: 2588-603 (1998)
Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc.
Curated by ChEMBL
| Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK). |
J Med Chem 41: 2588-603 (1998)
Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT |
More data for this Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc.
Curated by ChEMBL
| Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK) |
J Med Chem 41: 2588-603 (1998)
Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT |
More data for this Ligand-Target Pair | |
Insulin-like growth factor I receptor
(Homo sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc.
Curated by ChEMBL
| Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor |
J Med Chem 41: 2588-603 (1998)
Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory activity against Janus Kinase 3 protein tyrosine kinase. |
Bioorg Med Chem Lett 13: 3105-10 (2003)
BindingDB Entry DOI: 10.7270/Q2833RDR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
LEO Pharma A/S
Curated by ChEMBL
| Assay Description In vitro inhibition of KDR |
J Med Chem 48: 5412-4 (2005)
Article DOI: 10.1021/jm0504151 BindingDB Entry DOI: 10.7270/Q2319VD1 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase 17B (STK17B)
(Homo sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 353 | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Binding affinity to human DRAK2 |
J Med Chem 51: 7898-914 (2008)
Article DOI: 10.1021/jm8011036 BindingDB Entry DOI: 10.7270/Q2WS8T4C |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase SRPK1
(Homo sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 361 | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Binding affinity to human SRPK1 |
J Med Chem 51: 7898-914 (2008)
Article DOI: 10.1021/jm8011036 BindingDB Entry DOI: 10.7270/Q2WS8T4C |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milano-Bicocca
Curated by ChEMBL
| Assay Description Inhibition of FLT3 by ELISA-based kinase assay |
Bioorg Med Chem 18: 1482-96 (2010)
Article DOI: 10.1016/j.bmc.2010.01.011 BindingDB Entry DOI: 10.7270/Q2B56KPQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milano-Bicocca
Curated by ChEMBL
| Assay Description Inhibition of ABL by ELISA-based kinase assay |
Bioorg Med Chem 18: 1482-96 (2010)
Article DOI: 10.1016/j.bmc.2010.01.011 BindingDB Entry DOI: 10.7270/Q2B56KPQ |
More data for this Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milano-Bicocca
Curated by ChEMBL
| Assay Description Inhibition of ALK by ELISA-based kinase assay |
Bioorg Med Chem 18: 1482-96 (2010)
Article DOI: 10.1016/j.bmc.2010.01.011 BindingDB Entry DOI: 10.7270/Q2B56KPQ |
More data for this Ligand-Target Pair | |
cFMS -Tie-2 Chimera
(Homo sapiens (Human)) | BDBM17015
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8- | PDB MMDB
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johnson & Johnson Pharmaceutical
| Assay Description The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e... |
J Biol Chem 282: 4085-93 (2007)
Article DOI: 10.1074/jbc.M608182200 BindingDB Entry DOI: 10.7270/Q2NK3C8N |
More data for this Ligand-Target Pair | |