BDBM170709 US9085555, 137

SMILES: C[C@H]1C[C@H](N(C1)C(=O)Nc1cn(C(N)=O)c2ccccc12)C(=O)Nc1cccc(OC(F)(F)F)c1

InChI Key: InChIKey=WNNRIJLBPFMFLJ-DJJJIMSYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 170709   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM170709 (US9085555, 137) Show SMILES C[C@H]1C[C@H](N(C1)C(=O)Nc1cn(C(N)=O)c2ccccc12)C(=O)Nc1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C23H22F3N5O4/c1-13-9-19(20(32)28-14-5-4-6-15(10-14)35-23(24,25)26)31(11-13)22(34)29-17-12-30(21(27)33)18-8-3-2-7-16(17)18/h2-8,10,12-13,19H,9,11H2,1H3,(H2,27,33)(H,28,32)(H,29,34)/t13-,19-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Inhibition of recombinant human complement factor D catalytic domain using Z-Lys-thiobenzylester as substrate preincubated for 1 hr followed by subst...				J Med Chem 60: 5717-5735 (2017) Article DOI: 10.1021/acs.jmedchem.7b00425 BindingDB Entry DOI: 10.7270/Q2TB195V
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM170709 (US9085555, 137) Show SMILES C[C@H]1C[C@H](N(C1)C(=O)Nc1cn(C(N)=O)c2ccccc12)C(=O)Nc1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C23H22F3N5O4/c1-13-9-19(20(32)28-14-5-4-6-15(10-14)35-23(24,25)26)31(11-13)22(34)29-17-12-30(21(27)33)18-8-3-2-7-16(17)18/h2-8,10,12-13,19H,9,11H2,1H3,(H2,27,33)(H,28,32)(H,29,34)/t13-,19-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	7.5	25
NOVARTIS AG US Patent					Assay Description Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...				US Patent US9085555 (2015) BindingDB Entry DOI: 10.7270/Q2RN36MP
					More data for this Ligand-Target Pair