BDBM170759 US9085555, 187

SMILES: NC(=O)n1cc(NC(=O)N2CCCC[C@H]2C(=O)Nc2cccc(OC(F)(F)F)c2)c2ccccc12

InChI Key: InChIKey=RAVOHDSSRPXDSU-IBGZPJMESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 170759   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM170759 (US9085555, 187) Show SMILES NC(=O)n1cc(NC(=O)N2CCCC[C@H]2C(=O)Nc2cccc(OC(F)(F)F)c2)c2ccccc12 |r| Show InChI InChI=1S/C23H22F3N5O4/c24-23(25,26)35-15-7-5-6-14(12-15)28-20(32)19-10-3-4-11-30(19)22(34)29-17-13-31(21(27)33)18-9-2-1-8-16(17)18/h1-2,5-9,12-13,19H,3-4,10-11H2,(H2,27,33)(H,28,32)(H,29,34)/t19-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Inhibition of recombinant human complement factor D catalytic domain using Z-Lys-thiobenzylester as substrate preincubated for 1 hr followed by subst...				J Med Chem 60: 5717-5735 (2017) Article DOI: 10.1021/acs.jmedchem.7b00425 BindingDB Entry DOI: 10.7270/Q2TB195V
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM170759 (US9085555, 187) Show SMILES NC(=O)n1cc(NC(=O)N2CCCC[C@H]2C(=O)Nc2cccc(OC(F)(F)F)c2)c2ccccc12 |r| Show InChI InChI=1S/C23H22F3N5O4/c24-23(25,26)35-15-7-5-6-14(12-15)28-20(32)19-10-3-4-11-30(19)22(34)29-17-13-31(21(27)33)18-9-2-1-8-16(17)18/h1-2,5-9,12-13,19H,3-4,10-11H2,(H2,27,33)(H,28,32)(H,29,34)/t19-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.22E+4	n/a	n/a	n/a	n/a	7.5	25
NOVARTIS AG US Patent					Assay Description Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...				US Patent US9085555 (2015) BindingDB Entry DOI: 10.7270/Q2RN36MP
					More data for this Ligand-Target Pair