BDBM170890 US9085555, 318

SMILES: COC(=O)COc1ccc2n(cc(NC(=O)N3C[C@](C)(F)C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1)C(N)=O

InChI Key: InChIKey=JQHMOAUFRDLCDC-RXFWQSSRSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 170890   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM170890 (US9085555, 318) Show SMILES COC(=O)COc1ccc2n(cc(NC(=O)N3C[C@](C)(F)C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1)C(N)=O |r| Show InChI InChI=1S/C26H26ClF2N5O6/c1-26(29)9-20(23(36)31-10-14-4-3-5-17(27)22(14)28)34(13-26)25(38)32-18-11-33(24(30)37)19-7-6-15(8-16(18)19)40-12-21(35)39-2/h3-8,11,20H,9-10,12-13H2,1-2H3,(H2,30,37)(H,31,36)(H,32,38)/t20-,26+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	25
NOVARTIS AG US Patent					Assay Description Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...				US Patent US9085555 (2015) BindingDB Entry DOI: 10.7270/Q2RN36MP
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