BDBM171208 US9085555, 638

SMILES: CO[C@@H]1[C@@H](F)CN([C@@H]1C(=O)Nc1cccc(OC(F)(F)F)c1F)C(=O)Cn1nc(C(C)=O)c2cc(OCc3ncccn3)ccc12

InChI Key: InChIKey=JRVFNLHGYUEQCA-RHLLTPQKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 171208   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM171208 (US9085555, 638) Show SMILES CO[C@@H]1[C@@H](F)CN([C@@H]1C(=O)Nc1cccc(OC(F)(F)F)c1F)C(=O)Cn1nc(C(C)=O)c2cc(OCc3ncccn3)ccc12 |r| Show InChI InChI=1S/C29H25F5N6O6/c1-15(41)25-17-11-16(45-14-22-35-9-4-10-36-22)7-8-20(17)40(38-25)13-23(42)39-12-18(30)27(44-2)26(39)28(43)37-19-5-3-6-21(24(19)31)46-29(32,33)34/h3-11,18,26-27H,12-14H2,1-2H3,(H,37,43)/t18-,26-,27+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	25
NOVARTIS AG US Patent					Assay Description Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...				US Patent US9085555 (2015) BindingDB Entry DOI: 10.7270/Q2RN36MP
					More data for this Ligand-Target Pair