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SMILES: Clc1cnn(CCC(=O)NCc2ccnc(c2)-n2[nH]cc(-c3cccnc3)c2=O)c1

InChI Key: InChIKey=DMTRRNGKQDUYPV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 171830   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
von Hippel-Lindau disease tumor suppressor


(Homo sapiens (Human))		BDBM171830
PNG
(US9085572, 50)
Show SMILES Clc1cnn(CCC(=O)NCc2ccnc(c2)-n2[nH]cc(-c3cccnc3)c2=O)c1
Show InChI InChI=1S/C20H18ClN7O2/c21-16-11-25-27(13-16)7-4-19(29)24-9-14-3-6-23-18(8-14)28-20(30)17(12-26-28)15-2-1-5-22-10-15/h1-3,5-6,8,10-13,26H,4,7,9H2,(H,24,29)
PDB

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Similars
US Patent
n/an/a 1.90E+3n/an/an/an/a7.5n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair