BDBM172088 US10155002, Compound 94::US9090562, 94
SMILES: CCN(CC)Cc1ccc(cc1)-c1cc(N(CC)C2CCOCC2)c(C)c(c1)C(=O)NCc1c(C)cc(C)[nH]c1=O
InChI Key: InChIKey=UHPLNSCHNQCZNQ-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM172088 (US10155002, Compound 94 | US11052093, Compound 94 ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.46 | n/a | n/a | n/a | n/a | n/a | 25 |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US9090562 (2015) BindingDB Entry DOI: 10.7270/Q2057DPX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EZH2(Y641F) (Homo sapiens (Human)) | BDBM172088 (US10155002, Compound 94 | US11052093, Compound 94 ...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.07 | n/a | n/a | n/a | n/a | n/a | 25 |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US9090562 (2015) BindingDB Entry DOI: 10.7270/Q2057DPX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EZH2(Y641F) (Homo sapiens (Human)) | BDBM172088 (US10155002, Compound 94 | US11052093, Compound 94 ...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | n/a | n/a | 2.07 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EZH2(Y641F) (Homo sapiens (Human)) | BDBM172088 (US10155002, Compound 94 | US11052093, Compound 94 ...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.07 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US10155002 (2018) BindingDB Entry DOI: 10.7270/Q2KS6TM3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM172088 (US10155002, Compound 94 | US11052093, Compound 94 ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | n/a | n/a | 2.46 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM172088 (US10155002, Compound 94 | US11052093, Compound 94 ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US10155002 (2018) BindingDB Entry DOI: 10.7270/Q2KS6TM3 | |||||||||||
More data for this Ligand-Target Pair |