BDBM17253 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-{[(2,3-dihydroxypropyl)(methyl)amino]methyl}thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 55

SMILES: CN(CC(O)CO)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl

InChI Key: InChIKey=FLTXDVPKENYNGT-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 17253   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor X (Homo sapiens (Human))	BDBM17253 (3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...) Show SMILES CN(CC(O)CO)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl Show InChI InChI=1S/C23H22Cl3N3O4S/c1-29(10-17(31)11-30)9-13-12-34-21(20(13)26)23(33)28-19-7-4-15(25)8-18(19)22(32)27-16-5-2-14(24)3-6-16/h2-8,12,17,30-31H,9-11H2,1H3,(H,27,32)(H,28,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Berlex					Assay Description The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...				Bioorg Med Chem 15: 2127-46 (2007) Article DOI: 10.1016/j.bmc.2006.12.019 BindingDB Entry DOI: 10.7270/Q2MS3R1T
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM17253 (3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...) Show SMILES CN(CC(O)CO)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl Show InChI InChI=1S/C23H22Cl3N3O4S/c1-29(10-17(31)11-30)9-13-12-34-21(20(13)26)23(33)28-19-7-4-15(25)8-18(19)22(32)27-16-5-2-14(24)3-6-16/h2-8,12,17,30-31H,9-11H2,1H3,(H,27,32)(H,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	990	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Berlex					Assay Description The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...				Bioorg Med Chem 15: 2127-46 (2007) Article DOI: 10.1016/j.bmc.2006.12.019 BindingDB Entry DOI: 10.7270/Q2MS3R1T
					More data for this Ligand-Target Pair
Trypsin (Bos taurus (bovine))	BDBM17253 (3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...) Show SMILES CN(CC(O)CO)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl Show InChI InChI=1S/C23H22Cl3N3O4S/c1-29(10-17(31)11-30)9-13-12-34-21(20(13)26)23(33)28-19-7-4-15(25)8-18(19)22(32)27-16-5-2-14(24)3-6-16/h2-8,12,17,30-31H,9-11H2,1H3,(H,27,32)(H,28,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Berlex					Assay Description The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...				Bioorg Med Chem 15: 2127-46 (2007) Article DOI: 10.1016/j.bmc.2006.12.019 BindingDB Entry DOI: 10.7270/Q2MS3R1T
					More data for this Ligand-Target Pair