BDBM172717 US9090657, 24
SMILES: CC(C)[C@@H]1NC(=O)[C@H](CCC(C)=O)[C@H](O)[C@@H](C)[C@@H](O)\C=C\C=C\C[C@H](OC(=O)C2CCCN(N2)C(=O)[C@H](Cc2cc(O)cc(F)c2)NC1=O)C(\C)=C\C=C\C(=O)N1CCCCO1
InChI Key: InChIKey=CFLBTKFHBBDVKC-RROFBZPUSA-N
Data: 7 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Peptidyl-prolyl cis-trans isomerase A (Homo sapiens (Human)) | BDBM172717 (US9090657, 24) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
NEUROVIVE PHARMACEUTICAL AB US Patent | Assay Description The PPlase activity of recombinant CypA or D, produced by thrombin cleavage of GST-CypA or D, was determined by following the rate of hydrolysis of N... | US Patent US9090657 (2015) BindingDB Entry DOI: 10.7270/Q22Z148H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier organic anion transporter family member 1B1 (OATP1B1) (Homo sapiens (Human)) | BDBM172717 (US9090657, 24) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | 7.3 | 37 |
NEUROVIVE PHARMACEUTICAL AB US Patent | Assay Description To assess the inhibition of the OAT1B1 and OAT1B3 uptake transporters, an in vitro uptake transporter assay from Solvo Biotechnology Inc. was used. U... | US Patent US9090657 (2015) BindingDB Entry DOI: 10.7270/Q22Z148H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier organic anion transporter family member 1B3 (OATP1B3) (Homo sapiens (Human)) | BDBM172717 (US9090657, 24) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | 7.3 | 37 |
NEUROVIVE PHARMACEUTICAL AB US Patent | Assay Description To assess the inhibition of the OAT1B1 and OAT1B3 uptake transporters, an in vitro uptake transporter assay from Solvo Biotechnology Inc. was used. U... | US Patent US9090657 (2015) BindingDB Entry DOI: 10.7270/Q22Z148H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile salt export pump (BSEP) (Homo sapiens (Human)) | BDBM172717 (US9090657, 24) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.23E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
NEUROVIVE PHARMACEUTICAL AB US Patent | Assay Description To assess the inhibition of the MRP2, MRP3 and BSEP efflux transporters, an in vitro vesicular transporter assay from Solvo Biotechnology Inc. was us... | US Patent US9090657 (2015) BindingDB Entry DOI: 10.7270/Q22Z148H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Multidrug resistance-associated protein 2 (MRP2) (Homo sapiens (Human)) | BDBM172717 (US9090657, 24) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
NEUROVIVE PHARMACEUTICAL AB US Patent | Assay Description To assess the inhibition of the MRP2, MRP3 and BSEP efflux transporters, an in vitro vesicular transporter assay from Solvo Biotechnology Inc. was us... | US Patent US9090657 (2015) BindingDB Entry DOI: 10.7270/Q22Z148H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P-glycoprotein 1 (Homo sapiens (Human)) | BDBM172717 (US9090657, 24) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
NEUROVIVE PHARMACEUTICAL AB US Patent | Assay Description To assess the inhibition of the P-glycoprotein (Pgp/MDR1) transporter, an in vitro ATPase assay from Cyprotex was used. MDR1MDCK cells obtained from ... | US Patent US9090657 (2015) BindingDB Entry DOI: 10.7270/Q22Z148H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Multidrug resistance-associated protein 2 (MRP2) (Homo sapiens (Human)) | BDBM172717 (US9090657, 24) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
NEUROVIVE PHARMACEUTICAL AB US Patent | Assay Description To assess the inhibition of the MRP2, MRP3 and BSEP efflux transporters, an in vitro vesicular transporter assay from Solvo Biotechnology Inc. was us... | US Patent US9090657 (2015) BindingDB Entry DOI: 10.7270/Q22Z148H | |||||||||||
More data for this Ligand-Target Pair |