BDBM172940 US9096579, 42

SMILES: Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)NCC2CCOCC2)n1

InChI Key: InChIKey=TWCJOIQLWWMNQZ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 172940   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM172940 (US9096579, 42) Show SMILES Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)NCC2CCOCC2)n1 Show InChI InChI=1S/C23H24ClN7O2/c1-31-12-20(27-13-31)18-2-5-25-23(30-18)28-16-8-15-9-19(29-21(15)17(24)10-16)22(32)26-11-14-3-6-33-7-4-14/h2,5,8-10,12-14,29H,3-4,6-7,11H2,1H3,(H,26,32)(H,25,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US9096579 (2015) BindingDB Entry DOI: 10.7270/Q2F76B9H
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