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BDBM172947 US9096579, 49

SMILES: CN1C(=O)COCC11CCN(CC1)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Cl)c2[nH]1

InChI Key: InChIKey=COGDXHDOZNFDOW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 172947   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172947
PNG
(US9096579, 49)
Show SMILES CN1C(=O)COCC11CCN(CC1)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Cl)c2[nH]1
Show InChI InChI=1S/C26H27ClN8O3/c1-33-12-21(29-15-33)19-3-6-28-25(32-19)30-17-9-16-10-20(31-23(16)18(27)11-17)24(37)35-7-4-26(5-8-35)14-38-13-22(36)34(26)2/h3,6,9-12,15,31H,4-5,7-8,13-14H2,1-2H3,(H,28,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.700n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair