BDBM172951 US9096579, 53

SMILES: Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N2CCC(CC2)N2CCCC2=O)n1

InChI Key: InChIKey=QJYWZQZKOFYFRP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 172951   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM172951 (US9096579, 53) Show SMILES Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N2CCC(CC2)N2CCCC2=O)n1 Show InChI InChI=1S/C26H27ClN8O2/c1-33-14-22(29-15-33)20-4-7-28-26(32-20)30-17-11-16-12-21(31-24(16)19(27)13-17)25(37)34-9-5-18(6-10-34)35-8-2-3-23(35)36/h4,7,11-15,18,31H,2-3,5-6,8-10H2,1H3,(H,28,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US9096579 (2015) BindingDB Entry DOI: 10.7270/Q2F76B9H
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