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SMILES: Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1nc2ccccc2o1

InChI Key: InChIKey=LJYFCWCPJGFGJD-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 173020   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM173020
PNG
(US9096579, 122)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1nc2ccccc2o1
Show InChI InChI=1S/C26H22N8O2/c1-15-9-17(30-26-27-8-7-18(33-26)21-13-34(2)14-29-21)10-16-11-20(32-24(15)16)25(35)28-12-23-31-19-5-3-4-6-22(19)36-23/h3-11,13-14,32H,12H2,1-2H3,(H,28,35)(H,27,30,33)
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PC cid
PC sid
UniChem
US Patent
n/an/a 6.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair