BDBM173021 US9096579, 123

SMILES: Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1nc2ccncc2[nH]1

InChI Key: InChIKey=ZQUFBQQHQKSJIL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 173021   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM173021 (US9096579, 123) Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1nc2ccncc2[nH]1 Show InChI InChI=1S/C25H22N10O/c1-14-7-16(30-25-27-6-4-18(34-25)21-12-35(2)13-29-21)8-15-9-19(33-23(14)15)24(36)28-11-22-31-17-3-5-26-10-20(17)32-22/h3-10,12-13,33H,11H2,1-2H3,(H,28,36)(H,31,32)(H,27,30,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US9096579 (2015) BindingDB Entry DOI: 10.7270/Q2F76B9H
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM173021 (US9096579, 123) Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1nc2ccncc2[nH]1 Show InChI InChI=1S/C25H22N10O/c1-14-7-16(30-25-27-6-4-18(34-25)21-12-35(2)13-29-21)8-15-9-19(33-23(14)15)24(36)28-11-22-31-17-3-5-26-10-20(17)32-22/h3-10,12-13,33H,11H2,1-2H3,(H,28,36)(H,31,32)(H,27,30,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US9096579 (2015) BindingDB Entry DOI: 10.7270/Q2F76B9H
					More data for this Ligand-Target Pair