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SMILES: Cc1csc(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)n1

InChI Key: InChIKey=PPNLAXBCPARPGT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 173023   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM173023
PNG
(US9096579, 125)
Show SMILES Cc1csc(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)n1
Show InChI InChI=1S/C23H22N8OS/c1-13-6-16(28-23-24-5-4-17(30-23)19-10-31(3)12-26-19)7-15-8-18(29-21(13)15)22(32)25-9-20-27-14(2)11-33-20/h4-8,10-12,29H,9H2,1-3H3,(H,25,32)(H,24,28,30)
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Similars
US Patent
n/an/a 4.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair