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SMILES: CCn1nccc1CNC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1

InChI Key: InChIKey=QDIMVLCFXXSWJL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 173026   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM173026
PNG
(US9096579, 128)
Show SMILES CCn1nccc1CNC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C24H25N9O/c1-4-33-18(5-8-28-33)12-26-23(34)20-11-16-10-17(9-15(2)22(16)30-20)29-24-25-7-6-19(31-24)21-13-32(3)14-27-21/h5-11,13-14,30H,4,12H2,1-3H3,(H,26,34)(H,25,29,31)
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Similars
US Patent
n/an/a 3.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair