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SMILES: Cc1n[nH]cc1CNC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1

InChI Key: InChIKey=VYPDKXVZSAZFPT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 173033   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM173033
PNG
(US9096579, 135)
Show SMILES Cc1n[nH]cc1CNC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C23H23N9O/c1-13-6-17(28-23-24-5-4-18(30-23)20-11-32(3)12-26-20)7-15-8-19(29-21(13)15)22(33)25-9-16-10-27-31-14(16)2/h4-8,10-12,29H,9H2,1-3H3,(H,25,33)(H,27,31)(H,24,28,30)
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Similars
US Patent
n/an/a 8.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair